Investigation of green solvents for the extraction of phenol and natural alkaloids: Solvent and extractant selection

Y Wu; W Li; J Vovers; H Thuan Lu; GW Stevens; KA Mumford

Journal article

Investigation of green solvents for the extraction of phenol and natural alkaloids: Solvent and extractant selection

Y Wu, W Li, J Vovers, H Thuan Lu, GW Stevens, KA Mumford

Chemical Engineering Journal | Published : 2022

DOI: 10.1016/j.cej.2022.136054

Abstract

Green solvents have been gaining momentum to replace traditional volatile organic compounds (VOCs) in solvent extraction processes due to environmental and health concerns. In this work, phenol was used as a model compound for natural alkaloid extraction to find an appropriate alternative among green bio-derived solvents, including d-limonene, α-pinene, p-cymene, 2,5-dimethylfuran (DMF) and CyreneTM. Moreover, extractants including Cyanex 923®, trioctylphosphine oxide (TOPO), tri-butyl-phosphate (TBP) and Alamine 336 were evaluated to investigate the improvement to phenol extraction performance. The selection of extractants and green solvents is based on an evaluation matrix composing severa..

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University of Melbourne Researchers

April Li Author

Geoff Stevens Author

Kathryn Mumford Author

Hiep Thuan (Bill) Lu Author

Related Projects (1)

Environmentally Sustainable Solvents for Natural Pharmaceutical Extraction Processes

Australia supplies 25 per cent of the world's pain relieving medicinal opiates which contributes to a $200 million export industry for Austr..

Grants

Awarded by Australian Research Council

Funding Acknowledgements

The authors acknowledge the financial and technical support from Australian Research Council and SUN Pharma through an ARC linkage program (LP140100650) .